TABLE 3.
Role of yeast Polζ in extending primer ends opposite from DNA lesions
| DNA lesion | Nucleotide inserted | Inserter polymerase | Extender polymerase | Mode of lesion bypass |
|---|---|---|---|---|
| TT dimer | A | Polη | Polη | Error free |
| G | Polη | Polζ | Mutagenic | |
| (6-4) TT photoproduct | G | Polη | Polζ | Mutagenic |
| A | ? | Polζ | Error free | |
| Abasic site | A | Polδ | Polζ | |
| G | Polη | Polζ | Mostly mutagenic | |
| C | Rev1 | Polζ | ||
| 8-oxoG | C | Polη | Polη | Error free |
| A | Polδ | Polζ or Polη | Mutagenic | |
| m6G | C or T | Polη | Polη | Error free and mutagenic |
| T or C | Polδ | Polζ or Polη | Mutagenic and error free |