Skip to main content
PMC home page
Gut logoLink to Gut
. 1971 Jun;12(6):458–464. doi: 10.1136/gut.12.6.458

Controlled study of autoimmunization against liver in inbred rat strains 1

B P Maclaurin
PMCID: PMC1411662  PMID: 5090870

Abstract

By prolonged immunization of an inbred rat strain with isologous liver homogenate in Freund's complete adjuvant a low grade autoimmune `cholangitis' with periductular fibrosis has been demonstrated. The lesion could be transferred to isogeneic animals by serial spleen cell injections and was associated with mild but variable delayed skin sensitivity to a supernatant fraction of the liver homogenate. It is thought to be due to a combined cellular and antibody-mediated immune response, directed against bile duct constituents. Pulmonary (peribronchial) lesions have also been described in the same animals and are considered to be of similar origin and to represent a cross reaction with tissue of similar embryological (entodermal) origin. This appears to be the first description of periductular hepatic fibrosis clearly resulting from an autoimmune reaction and may provide a model for further study of rather similar histological reactions known to occur in man.

Full text

PDF

Images in this article

461Fig. 1a
on p.461
461Fig. 1b
on p.461
461Fig. 2
on p.461
462Fig. 3
on p.462

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASHERSON G. L., DUMONDE D. C. Characterization of auto-antibodies produced in the rabbit by the injection of rat liver. Br J Exp Pathol. 1962 Feb;43:12–20. [PMC free article] [PubMed] [Google Scholar]
  2. CROWLE A. J., HU C. C. INHIBITION OF THE DEVELOPMENT OF DELAYED HYPERSENSITIVITY BY TREATMENT WITH ANTISERUM. J Immunol. 1965 Apr;94:555–562. [PubMed] [Google Scholar]
  3. ELKINS W. L. INVASION AND DESTRUCTION OF HOMOLOGOUS KIDNEY BY LOCALLY INOCULATED LYMPHOID CELLS. J Exp Med. 1964 Sep 1;120:329–348. doi: 10.1084/jem.120.3.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Heslop B. F. Histocompatibility antigens in the rat: the AS2 strain in relation to the AS, BS and HS strains. Aust J Exp Biol Med Sci. 1968 Aug;46(4):479–491. doi: 10.1038/icb.1968.41. [DOI] [PubMed] [Google Scholar]
  5. MISTILIS S. P. PERICHOLANGITIS AND ULCERATIVE COLITIS. I. PATHOLOGY, ETIOLOGY, AND PATHOGENESIS. Ann Intern Med. 1965 Jul;63:1–16. doi: 10.7326/0003-4819-63-1-1. [DOI] [PubMed] [Google Scholar]
  6. PARONETTO F., SCHAFFNER F., MUTTER R. D., KNIFFEN J. C., POPPER H. CIRCULATING ANTIBODIES TO BILE DUCTULAR CELLS IN VARIOUS LIVER DISEASES. JAMA. 1964 Feb 15;187:503–506. doi: 10.1001/jama.1964.03060200035006. [DOI] [PubMed] [Google Scholar]
  7. RUBIN E., SCHAFFNER F., POPPER H. PRIMARY BILIARY CIRRHOSIS. CHRONIC NON-SUPPURATIVE DESTRUCTIVE CHOLANGITIS. Am J Pathol. 1965 Mar;46:387–407. [PMC free article] [PubMed] [Google Scholar]
  8. STAUFFER M. H., SAUER W. G., DEARING W. H., BAGGENSTOSS A. H. THE SPECTRUM OF CHOLESTATIC HEPATIC DISEASE. JAMA. 1965 Mar 8;191:829–837. doi: 10.1001/jama.1965.03080100047011. [DOI] [PubMed] [Google Scholar]
  9. Scheiffarth F., Warnatz H., Mayer K. Studies concerning the importance of mononuclear cells in the development of experimental hepatitis. J Immunol. 1967 Feb;98(2):396–401. [PubMed] [Google Scholar]
  10. WEIR D. M. LIVER AUTOANTIBODIES IN THE RAT. Immunology. 1963 Nov;6:581–591. [PMC free article] [PubMed] [Google Scholar]
  11. Warnatz H., Scheiffarth F., Schwarz R. Tierexperimentelle Untersuchungen zur Pathogenese der chronischen Hepatitis. II. Serologische Studien nach Sensibilisierung mit homologen Leberzellfraktionen. Virchows Arch Pathol Anat Physiol Klin Med. 1965 Aug 13;339(4):364–371. [PubMed] [Google Scholar]
  12. Warnatz H., Scheiffarth F., Wolf F., Schmidt H. J. Autoradiographic experiments concerning the importance of mononuclear cells in experimental hepatitis. J Immunol. 1967 Feb;98(2):402–405. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES