TABLE 2.

P. brasiliensis clusters similar to C. albicans genes involved in virulence and pathogenicity

Gene group and P. brasiliensis cluster IDa	C. albicans homologue (NCBI protein accession no.)	Main feature and/or role	BLAST E-value/% identity/% similarity
Metabolic genes
PbCC003-B07	ADE2 (AAC49742)	Nucleotide synthesis	4e-21/58/77
PbCC006-G01	HIS1 (P46586)	Amino acid synthesis	9e-57/61/73
PbCC002-G09	MLS1 (AAF34695)	Malate synthase, glyoxylate cycle	8e-30/56/69
PbCC009-C01	ICL1 (AAF34690)	Isocitrate lyase, glyoxylate cycle	4e-66/74/85
PbCC015-E02	HEM3 (094048)	Hemosynthesis	5e-16/39/60
PbCC001-E02			1e-14/41/63
PbCS033-B09	PLB1 (AAC72296)	Phospholipase	1e-09/43/55
Cell wall genes
PbCC011-D01	CHS2 (S20538)	Chitin synthase; cell wall synthesis	4e-23/51/73
PbCC013-B07	CHS3 (P30573)		2e-21/72/88
PbCS003-C01			3e-31/43/60
PbCS008-H07			5e-30/43/51
PbCC004-H02	HWP1 (P46593)	Transglutaminase, adhesion	2e-08/39/50
PbCS001-B02	INT1 (P53705)	Integrin, adhesion	1e-49/33/56
PbCS006-A05	MNT1 (CAA67930)	Mannosyl transferase	1e-31/55/80
PbCC003-D08	PHR1 (AAG16995)	Glycosidase GPI-anchored; cell wall structure	2e-70/49/68
PbCC013-H06	PHR2 (AAG16996)		2e-10/35/54
PbCS011-F12	PMT1 (AAC31119)	Mannosyl transferase	1e-07/31/48
PbCC004-C02	RBT5 (AAG09790)	Secreted cell wall protein, GPI anchor	1e-07/30/47
PbCC008-G03			4e-16/31/45
PbCC002-C04	BGL2 (AAA21151)	β-Glucosyltransferase; cell wall synthesis	1e-60/41/57
Signal transduction genes
PbCS022-F02	CST20 (AAB38875)	MEKK kinase hyphal formation	2e-77/77/88
PbCC004-A02	CPP1 (P43078)	Phosphatase, hyphal formation	6e-04/44/64
PbCC011-F09	CEK1 (A47211)	MAPK, hyphal formation	8e-04/29/48
PbCS023-G05	Protein kinase A (AAF64072)	Hyphal formation	3e-15/43/56
PbCC010-A10	CDC42 (AAB69764)	Cell division control protein, hyphal formation	1e-15/64/76
PbCS021-A08	GEF (Q9UQX7)	Ras-like protein, hyphal formation	4e-21/33/54

^aID, identification.