TABLE 3.
P. brasiliensis clusters that could play a role either in temperature-induced dimorphic transition or in the infection process
| Gene or protein type and P. brasiliensis cluster IDa | Homologue (NCBI protein accession no.) | Main feature and/or role | BLAST E-value/ % identity/ % similarity |
|---|---|---|---|
| Cell wall genes | |||
| PbCC011-D01 | C. albicans (BAA19847) | Chitin synthase regulatory factor | 4e-23/51/73 |
| PbCS022-H12 | S. cerevisiae CHS6 (NP_012436) | Chitin biosynthesis protein | 4e-04/30/49 |
| PbCC002-F03 | H. capsulatum (AAG41982) | Chitinase | 4e-20/39/50 |
| PbCC012-F03 | S. cerevisiae ECM27 (NP_012640) | Protein involved in the cell wall biogenesis and arquitecture | 6e-09/46/71 |
| Heat shock proteins | |||
| PbCC003-E08 | S. cerevisiae SIS1 (NP_014391) | Induced by heat shock | 5e-07/71/83 |
| PbCC004-A04 | S. cerevisiae HFM1 (NP_010978.1) | Heat shock - inducible inhibitor of cell growth | 7e-27/48/66 |
| PbCC003-G05 | S. cerevisiae STI1 (NP_014670) | Induced by heat shock | 2e-23/52/65 |
| Signal transduction genes | |||
| PbCC002-D10 | C. albicans PKC1 (P43057) | Protein kinase C | 3e-25/55/75 |
| PbCC011-H05 | H. capsulatum (AAC27509) | Calmodulin | 3e-27/39/62 |
| PbCS011-H09 | S. cerevisiae VTC1 (NP_010995) | Protein that acts as a negative regulator of the CDC42 protein | 2e-21/68/80 |
| Miscellaneous | |||
| PbCC006-H02 | M. grisea (AAK73019) | Ceramide glucosyl synthase | 8e-49/48/66 |
| PbCC028-E03 | S. cerevisiae YCF1 (NP_010419) | Glutathione S-conjugate vacuolar transporter | 2e-14/60/75 |
a
ID, identification.