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. 1978 Jul;19(7):587–592. doi: 10.1136/gut.19.7.587

Sialic acids of human large bowel mucosa: o-acylated variants in normal and malignant states.

C M Rogers, K B Cooke, M I Filipe
PMCID: PMC1412088  PMID: 680592

Abstract

Five sialic acid variants have been demonstrated in normal, 'transitional', and tumour extracts of human large bowel mucosa by thin-layer chromatography. Two-dimensional thin-layer chromatography, with intermediate alkaline hydrolysis, confirmed that the variants were N-acetyl neuraminic acids with additional O-acylation. Cases studied so far show changes in the proportions of these variants in malignancy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOHM P., DAUBER S., BAUMEISTER L. Uber Neuraminsäure, ihr Vorkommen und ihre Bestimmung im Serum. Klin Wochenschr. 1954 Apr 1;32(13-14):289–292. doi: 10.1007/BF01467396. [DOI] [PubMed] [Google Scholar]
  2. Buscher H. P., Casals-Stenzel J., Schaufer R. New sialic acids. Identification of N-glycoloyl-O-acetylneuraminic acids and N-acetyl-O-glycoloylneuraminic acids by improved methods for detection of N-acyl and O-acyl groups and by gas-liquid chromatography. Eur J Biochem. 1974 Dec 16;50(1):71–82. doi: 10.1111/j.1432-1033.1974.tb03873.x. [DOI] [PubMed] [Google Scholar]
  3. Filipe M. I., Branfoot A. C. Mucin histochemistry of the colon. Curr Top Pathol. 1976;63:143–178. doi: 10.1007/978-3-642-66481-6_5. [DOI] [PubMed] [Google Scholar]
  4. Filipe M. I., Cooke K. B. Changes in composition of mucin in the mucosa adjacent to carcinoma of the colon as compared with the normal: a biochemical investigation. J Clin Pathol. 1974 Apr;27(4):315–318. doi: 10.1136/jcp.27.4.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Filipe M. I. The value of a study of the mucosubstances in rectal biopsies from patients with carcinoma of the rectum and lower sigmoid in the diagnosis of premalignant mucosa. J Clin Pathol. 1972 Feb;25(2):123–128. doi: 10.1136/jcp.25.2.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Filipe M. I. Value of histochemical reactions for mucosubstances in the diagnosis of certain pathological conditions of the colon and rectum. Gut. 1969 Jul;10(7):577–586. doi: 10.1136/gut.10.7.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gold D. V., Miller F. Characterization of human colonic mucoprotein antigen. Immunochemistry. 1974 Jul;11(7):369–375. doi: 10.1016/0019-2791(74)90190-6. [DOI] [PubMed] [Google Scholar]
  8. Lipkin M., Deschner E., Troncale F. Cell differentiation and the development of colonic neoplasms. Gastroenterology. 1970 Aug;59(2):303–307. [PubMed] [Google Scholar]
  9. Reid P. E., Culling C. F., Tsang W. C., Clay M. G., Ramey C. W., Dunn W. L. The demonstration of O-acetylated sialic acids in colonic epithelial glycoproteins. Can J Biochem. 1975 Mar;53(3):388–391. doi: 10.1139/o75-053. [DOI] [PubMed] [Google Scholar]

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