Abstract
A quantitative perfusion method has been used to study intestinal absorption of two dipeptides—glycyl-glycine and glycyl-l-alanine—in normal subjects. In each case, the constituent amino acids were absorbed faster when presented as dipeptides than as free amino acids, suggesting intact dipeptide transport. During absorption constituent amino acids were measured within the lumen and it is suggested that these represent amino acids which have diffused back to the lumen after absorption as dipeptide.
Portal blood analyses during absorption of a third dipeptide, glycyl-l-lysine, have shown that this dipeptide, known to be transported intact from the intestinal lumen, is hydrolysed to its constitutent amino acids before it reaches portal venous blood.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adibi S. A. Intestinal transport of dipeptides in man: relative importance of hydrolysis and intact absorption. J Clin Invest. 1971 Nov;50(11):2266–2275. doi: 10.1172/JCI106724. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Asatoor A. M., Cheng B., Edwards K. D., Lant A. F., Matthews D. M., Milne M. D., Navab F., Richards A. J. Intestinal absorption of two dipeptides in Hartnup disease. Gut. 1970 May;11(5):380–387. doi: 10.1136/gut.11.5.380. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Craft I. L., Geddes D., Hyde C. W., Wise I. J., Matthews D. M. Absorption and malabsorption of glycine and glycine peptides in man. Gut. 1968 Aug;9(4):425–437. doi: 10.1136/gut.9.4.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Crampton R. F., Gangolli S. D., Simson P., Matthews D. M. Rates of absorption by rat intestine of pancreatic hydrolysates of proteins and their corresponding amino acid mixtures. Clin Sci. 1971 Nov;41(5):409–417. doi: 10.1042/cs0410409. [DOI] [PubMed] [Google Scholar]
- Fern E. B., Hider R. C., London D. R. The sites of hydrolysis of dipeptides containing leucine and glycine by rat jejunum in vitro. Biochem J. 1969 Oct;114(4):855–861. doi: 10.1042/bj1140855. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fleshler B., Butt J. H., Wismar J. D. Absorption of glycine and L-alanine by the human jejunum. J Clin Invest. 1966 Sep;45(9):1433–1441. doi: 10.1172/JCI105451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heizer W. D., Laster L. Peptide hydrolase activities of the mucosa of human small intestine. J Clin Invest. 1969 Jan;48(1):210–228. doi: 10.1172/JCI105970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hellier M. D., Perrett D., Holdsworth C. D. Dipeptide absorption in cystinuria. Br Med J. 1970 Dec 26;4(5738):782–783. doi: 10.1136/bmj.4.5738.782. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matthews D. M., Craft I. L., Geddes D. M., Wise I. J., Hyde C. W. Absorption of glycine and glycine peptides from the small intestine of the rat. Clin Sci. 1968 Dec;35(3):415–424. [PubMed] [Google Scholar]
- NEWEY H., SMYTH D. H. Intracellular hydrolysis of dipeptides during intestinal absorption. J Physiol. 1960 Jul;152:367–380. doi: 10.1113/jphysiol.1960.sp006493. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nixon S. E., Mawer G. E. The digestion and absorption of protein in man. 2. The form in which digested protein is absorbed. Br J Nutr. 1970 Mar;24(1):241–258. doi: 10.1079/bjn19700024. [DOI] [PubMed] [Google Scholar]
- Peters T. J., MacMahon M. T. The absorption of glycine and glycine oligopeptides by the rat. Clin Sci. 1970 Dec;39(6):811–821. doi: 10.1042/cs0390811. [DOI] [PubMed] [Google Scholar]
- Peters T. J. The subcellular localization of di- and tri-peptide hydrolase activity in guinea-pig small intestine. Biochem J. 1970 Nov;120(1):195–203. doi: 10.1042/bj1200195. [DOI] [PMC free article] [PubMed] [Google Scholar]