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. 1973 Aug;14(8):637–641. doi: 10.1136/gut.14.8.637

The metabolism of salicylazosulphapyridine in ulcerative colitis

II The relationship between metabolites and the progress of the disease studied in outpatients

PMCID: PMC1412752  PMID: 18668841

Abstract

Serum concentrations of salicylazosulphapyridine (SASP), sulphapyridine (SP), and 5-aminosalicylic acid (5-ASA) were measured in 64 outpatients with ulcerative colitis. About 90% of the patients in remission had serum total SP concentrations above 20 μg/ml. Seven patients, however, had active disease despite a serum total SP concentration > 20 μg/ml. The SASP and the individual SP metabolites did not show any correlation with the disease state. Three g per day seems to be the most effective dose. Plain and enteric-coated tablets produced similar concentrations at equivalent dosage. Side effects due to SASP were frequent in patients who had a total SP concentration > 50 μg/ml of serum.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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