Skip to main content
NCBI home page
Gut logoLink to Gut
. 1973 Dec;14(12):983–987. doi: 10.1136/gut.14.12.983

Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome 1

R F Harvey, A E Read
PMCID: PMC1412875  PMID: 4785287

Abstract

Magnesium sulphate, a substance known to cause release of cholecystokinin (CCK) from the small intestinal mucosa, was given by mouth (dose 0·1g/kg in 150 ml water) to 20 patients with the irritable bowel syndrome. A rapid increase in colonic segmental motor activity (onset within two to six minutes in most cases) was seen (percentage activity increased from 16·2 to 23·7 p<0·05; mean wave amplitude from 7·1 to 9·1 cm H2O, NS; motility index from 144 to 259, p<0·01). This increase was most marked in 10 patients who complained of attacks of abdominal pain after food (16·1 to 29·8%, p<0·01; 6·8 to 9·6 cm H2O, p<0·05; 135 to 350, p<0·05), and after the magnesium sulphate three of these patients experienced an attack of their usual pain. These findings provide further evidence that `functional' abdominal pain after food may in some cases be related to an exaggerated intestinal motor response to cholecystokinin.

Full text

PDF
983

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADLERCREUTZ E., PETTERSSON T., ADLERCREUTZ H., GRIBBE P., WEGELIUS C. Effect of cholecystokinin on duodenal tonus and motility. Acta Med Scand. 1960 Aug 10;167:339–342. doi: 10.1111/j.0954-6820.1960.tb03556.x. [DOI] [PubMed] [Google Scholar]
  2. ATKINSON M., EDWARDS D. A., HONOUR A. J., ROWLANDS E. N. Comparison of cardiac and pyloric sphincters; a manometric study. Lancet. 1957 Nov 9;273(7002):918–922. doi: 10.1016/s0140-6736(57)92381-4. [DOI] [PubMed] [Google Scholar]
  3. Berry H., Flower R. J. The assay of endogenous cholecystokinin and factors influencing its release in the dog and cat. Gastroenterology. 1971 Mar;60(3):409–420. [PubMed] [Google Scholar]
  4. CHAUDHARY N. A., TRUELOVE S. C. Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. III. Effects of emotions. Gastroenterology. 1961 Jan;40:27–36. [PubMed] [Google Scholar]
  5. CHAUDHARY N. A., TRUELOVE S. C. The irritable colon syndrome. A study of the clinical features, predisposing causes, and prognosis in 130 cases. Q J Med. 1962 Jul;31:307–322. [PubMed] [Google Scholar]
  6. CONNELL A. M., JONES F. A., ROWLANDS E. N. MOTILITY OF THE PELVIC COLON. IV. ABDOMINAL PAIN ASSOCIATED WITH COLONIC HYPERMOTILITY AFTER MEALS. Gut. 1965 Apr;6:105–112. doi: 10.1136/gut.6.2.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DAHLGREN S. THE AFFERENT LOOP SYNDROME. Acta Chir Scand Suppl. 1964;19:SUPPL 327–327:1+. [PubMed] [Google Scholar]
  8. DAVIDSON M., SLEISENGER M. H., ALMY T. P., LEVINE S. Z. Studies of distal colonic motility in children. II. Propulsive activity in diarrheal states. Pediatrics. 1956 Jun;17(6):820–832. [PubMed] [Google Scholar]
  9. Dahlgren S. Cholecystokinin: pharmacology and clinical use. Acta Chir Scand Suppl. 1966;357:256–260. [PubMed] [Google Scholar]
  10. Grossi F., Messina B., Del Duca T., Ricci M., Messini M. Attività peristaltica di massa del colon in seguito a somministrazione di "Cecekin". Prospettive di azioni umorali sulla motilità del colon. Clin Ter. 1966 Apr 30;37(2):117–121. [PubMed] [Google Scholar]
  11. Harvey R. F., Dowsett L., Hartog M., Read A. E. A radioimmunoassay for cholecystokinin-pancreozymin. Lancet. 1973 Oct 13;2(7833):826–828. doi: 10.1016/s0140-6736(73)90863-5. [DOI] [PubMed] [Google Scholar]
  12. Harvey R. F., Read A. E. Effect of cholecystokinin on colonic motility and symptoms in patients with the irritable-bowel syndrome. Lancet. 1973 Jan 6;1(7793):1–3. doi: 10.1016/s0140-6736(73)91219-1. [DOI] [PubMed] [Google Scholar]
  13. Holdstock D. J., Misiewicz J. J., Waller S. L. Observations on the mechanism of abdominal pain. Gut. 1969 Jan;10(1):19–31. doi: 10.1136/gut.10.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Misiewicz J. J., Waller S. L., Holdstock D. J. Gastrointestinal motility and gastric secretion during intravenous infusions of gastrin II. Gut. 1969 Sep;10(9):723–729. doi: 10.1136/gut.10.9.723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Painter N. S. Irritable or irritated bowel. Br Med J. 1972 Apr 1;2(5804):46–46. doi: 10.1136/bmj.2.5804.46-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Parker J. G., Beneventano T. C. Acceleration of small bowel contrast study by cholecystokinin. Gastroenterology. 1970 May;58(5):679–684. [PubMed] [Google Scholar]
  17. Valberg L. S., Jabbari M., Kerr J. W., Curtis A. C., Ramchand S., Prentice R. S. Biliary pain in young women in the absnece of gallstones. Gastroenterology. 1971 Jun;60(6):1020–1026. [PubMed] [Google Scholar]
  18. Waller S. L., Carvalhinhos A., Misiewicz J. J., Russell R. I. Effect of cholecystokinin on colonic motility. Lancet. 1973 Feb 3;1(7797):264–264. doi: 10.1016/s0140-6736(73)90104-9. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES