Skip to main content
NCBI home page
Gut logoLink to Gut
. 1974 Jun;15(6):444–449. doi: 10.1136/gut.15.6.444

Functional differentiation of human jejunum and ileum: A comparison of the handling of glucose, peptides, and amino acids

D B A Silk, Joan P W Webb, Annette E Lane, M L Clark, A M Dawson
PMCID: PMC1413011  PMID: 4852103

Abstract

The characteristics of glucose, glycine, L-alanine, and glycyl-L-alanine absorption from the jejunum and ileum have been compared in normal human subjects. A perfusion technique has been used, and correct positioning of the perfusion tube has been confirmed by measuring the differential jejunal and ileal handling of bicarbonate.

Glucose and glycine were absorbed faster from the jejunum than from the ileum of all subjects studied, and L-alanine was absorbed faster from the jejunum than from the ileum in five out of six subjects studied. In contrast, the dipeptide glycyl-L-alanine was absorbed at comparable rates from the jejunum and ileum. Higher concentrations of free amino acids were detected in the luminal contents aspirated during the ileal dipeptide perfusions.

These results emphasize the importance of oligopeptide transport in the absorption of protein digestion products, especially in the human ileum, and the practical implications of these findings are discussed.

Full text

PDF
444

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Addison J. M., Burston D., Matthews D. M. Carnosine transport by hamster jejunum in vitro and its inhibition by other di- and tripeptides. Clin Sci. 1973 Jul;45(1):3P–4P. doi: 10.1042/cs045003pa. [DOI] [PubMed] [Google Scholar]
  2. Addison J. M., Burston D., Matthews D. M. Evidence for active transport of the dipeptide glycylsarcosine by hamster jejunum in vitro. Clin Sci. 1972 Dec;43(6):907–911. doi: 10.1042/cs0430907. [DOI] [PubMed] [Google Scholar]
  3. Adibi S. A. Intestinal transport of dipeptides in man: relative importance of hydrolysis and intact absorption. J Clin Invest. 1971 Nov;50(11):2266–2275. doi: 10.1172/JCI106724. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Adibi S. A., Mercer D. W. Protein digestion in human intestine as reflected in luminal, mucosal, and plasma amino acid concentrations after meals. J Clin Invest. 1973 Jul;52(7):1586–1594. doi: 10.1172/JCI107335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Asatoor A. M., Cheng B., Edwards K. D., Lant A. F., Matthews D. M., Milne M. D., Navab F., Richards A. J. Intestinal absorption of two dipeptides in Hartnup disease. Gut. 1970 May;11(5):380–387. doi: 10.1136/gut.11.5.380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BORGSTROM B., DAHLQVIST A., LUNDH G., SJOVALL J. Studies of intestinal digestion and absorption in the human. J Clin Invest. 1957 Oct;36(10):1521–1536. doi: 10.1172/JCI103549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HOLDSWORTH C. D., DAWSON A. M. THE ABSORPTION OF MONOSACCHARIDES IN MAN. Clin Sci. 1964 Dec;27:371–379. [PubMed] [Google Scholar]
  8. Hellier M. D., Holdsworth C. D., McColl I., Perrett D. Dipeptide absorption in man. Gut. 1972 Dec;13(12):965–969. doi: 10.1136/gut.13.12.965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LIN E. C., WILSON T. H. Transport of L-tyrosine by the small intestine in vitro. Am J Physiol. 1960 Jul;199:127–130. doi: 10.1152/ajplegacy.1960.199.1.127. [DOI] [PubMed] [Google Scholar]
  10. Lindberg T. Intestinal dipeptidases. Dipeptidase activity in the mucosa of the gastrointestinal tract of the adult human. Acta Physiol Scand. 1966 Apr;66(4):437–443. doi: 10.1111/j.1748-1716.1966.tb03221.x. [DOI] [PubMed] [Google Scholar]
  11. MATTHEWS D. M., LASTER L. KINETICS OF INTESTINAL ACTIVE TRANSPORT OF FIVE NEUTRAL AMINO ACIDS. Am J Physiol. 1965 Apr;208:593–600. doi: 10.1152/ajplegacy.1965.208.4.593. [DOI] [PubMed] [Google Scholar]
  12. Nixon S. E., Mawer G. E. The digestion and absorption of protein in man. 1. The site of absorption. Br J Nutr. 1970 Mar;24(1):227–240. doi: 10.1079/bjn19700023. [DOI] [PubMed] [Google Scholar]
  14. Phillips S. F., Summerskill W. H. Water and electrolyte transport during maintenance of isotonicity in human jejunum and ileum. J Lab Clin Med. 1967 Oct;70(4):686–698. [PubMed] [Google Scholar]
  15. Rubino A., Field M., Shwachman H. Intestinal transport of amino acid residues of dipeptides. I. Influx of the glycine residue of glycyl-L-proline across mucosal border. J Biol Chem. 1971 Jun 10;246(11):3542–3548. [PubMed] [Google Scholar]
  16. SKEGGS L. T., Jr, HOCHSTRASSER H. MULTIPLE AUTOMATIC SEQUENTIAL ANALYSIS. Clin Chem. 1964 Oct;10:918–936. [PubMed] [Google Scholar]
  17. Schedl H. P., Miller K. L., Wilson H. D., Flores P. Alpha-aminoisobutyric acid transport and tissue concentration at various intestinal sites. Am J Physiol. 1969 May;216(5):1131–1138. doi: 10.1152/ajplegacy.1969.216.5.1131. [DOI] [PubMed] [Google Scholar]
  18. Silk D. B., Marrs T. C., Addison J. M., Burston D., Clark M. L., Matthews D. M. Absorption of amino acids from an amino acid mixture simulating casein and a tryptic hydrolysate of casein in man. Clin Sci Mol Med. 1973 Nov;45(5):715–719. doi: 10.1042/cs0450715. [DOI] [PubMed] [Google Scholar]
  19. Silk D. B., Perrett D., Clark M. L. Intestinal transport of two dipeptides containing the same two neutral amino acids in man. Clin Sci Mol Med. 1973 Sep;45(3):291–299. doi: 10.1042/cs0450291. [DOI] [PubMed] [Google Scholar]
  20. Silk D. B., Perrett D., Webb J. P., Clark M. L. Absorption of two tripeptides by the human small intestine: a study using a perfusion technique. Clin Sci Mol Med. 1974 Mar;46(3):393–402. doi: 10.1042/cs0460393. [DOI] [PubMed] [Google Scholar]
  21. Silk D. B. Progress report. Peptide absorption in man. Gut. 1974 Jun;15(6):494–501. doi: 10.1136/gut.15.6.494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. WILSON T. H., KAZYAK L. Acid-base changes across the wall of hamster and rat intestine. Biochim Biophys Acta. 1957 Apr;24(1):124–132. doi: 10.1016/0006-3002(57)90154-3. [DOI] [PubMed] [Google Scholar]
  23. Wingate D. L., Sandberg R. J., Phillips S. F. A comparison of stable and 14 C-labelled polyethylene glycol as volume indicators in the human jejunum. Gut. 1972 Oct;13(10):812–815. doi: 10.1136/gut.13.10.812. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES