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. 2006 Mar 15;20(6):689–699. doi: 10.1101/gad.1400506

Figure 1.

Figure 1.

Arylpyrazole compounds differentially affect cell growth and differentiation. (A) Effects of arylpyrazole compounds on A549 cell proliferation. A549 cells were treated with either DMSO, dexamethasone (0.1 μM), or arylpyrazole compounds (1 μM) for 5 d, and the relative ATP levels were measured. The data represent the mean (standard error of the mean, SEM) of the percent of ATP levels (dexamethasone or arylpyrazole compound-treated divided by the DMSO-treated) from four experiments. (B) Effects of arylpyrazole compounds on 3T3-L1 adipocyte differentiation. Confluent cultures of 3T3-L1 cells were placed in differentiation medium that contained IBMX, insulin with either DMSO, dexamethasone (1 μM), prednisolone (1 μM), or various arylpyrazole compounds (1 μM) as indicated. Oil Red staining was used to measure the extent of adipocyte differentiation. The data represent the mean (SEM) of Oil Red concentration from three experiments. (C) The effects of arylpyrazole compounds on MC3T3-E1 osteoblast differentiation. MC3T3-E1 cells were grown to confluence and then placed in differentiation medium that contained either DMSO, dexamethasone (1 μM), prednisolone (1 μM), or various arylpyrazole compounds (1 μM) as indicated. Alizarin Red staining was used to measure the extent of osteoblast differentiation. Data are averaged (with SEM) from four independent experiments.