Figure 11.

COX-2 immunoreactivity in ALS spinal cord found in microglial cells/macrophages predominantly in white matter. (A) Autoradiographic localisation of ³ [H] PK11195 in a spinal cord from a patient with ALS co-located with CD68 (D) (Scale bars = 1000 μm). The square indicates the area where subsequent CD68 and COX-2 images were taken from. B) And E) Microglial cells/macrophage -like immunostaining with CD68 antibody (Scale bars = 200 μm and 100 μm respectively). C) And F) Microglial cells/macrophage-like immunostaining with COX-2 (Scale bars = 200 μm and 100 μm respectively).