Fig. 3.

GCR suppression by Ku overexpression after MMS treatment is mediated by its crosstalk with cell cycle checkpoints. (A) Ku overexpression suppressed GCR formation after MMS treatment. (B) GCRs were still suppressed by Ku overexpression in the lig4 strain. Mutations, which inactivate cell cycle checkpoints, abolished the suppression of GCR by Ku overexpression after MMS treatment. (C) rad24. (D) sgs1. (E) dpb11–1. (F) mec1. “+” and “−” represent the presence and absence of Ku overexpression or the treatment and no treatment of 0.05% MMS, respectively.