Fig. 2.
Rapid T3SS-dependent inactivation of SGLT-1. (A) Import of the nonmetabolizable glucose analog 14C-labeled AMG [in disintegrations per minute (DPM)] by SGLT-1 is inhibited by EPEC but not the effector delivery mutant espA, in a dose-dependent manner (n = 3; mean ± SE). Statistical significance (∗) between uninfected and indicated infected series (horizontal lines) determined by one-way ANOVA with a post hoc Tukey’s test revealing where significance lies. (B) Percentage of the apical surface covered by EPEC after a 30-min infection at the indicated moi (EPEC/host cell) quantified after SEM evaluation (n = 3; mean ± SE).