Fig. 3.

Long-term effects of NRG infusion on SVZ cell proliferation. Both single (A–D) and continuous (E–G) injections of NRG2 increased the number of BrdUrd⁺ cells significantly (C and D), whereas NRG1 induced clustering of BrdUrd⁺ cells (arrowheads, B and F). Similarly, when BrdUrd was administered during the last 24 h of the 7-day NRG infusion period to preferentially label fast-dividing population of SVZ precursors, both NRG1 and -2 increased the number of BrdUrd⁺ cells. NRG1, as before, induced BrdUrd⁺ cell clustering (arrowhead, J). White asterisks indicate the position of the ventricles. Number of days of NRG and BrdUrd administration is indicated (Left). Data shown are mean ± SEM; ∗, P < 0.01, Student’s t test. [Scale bar: 50 μm (A, C, E, G, I, K); 65 μm (B, F, J)]. Also see Tables 2, 4, and 5 and Supporting Text.