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ROMK channel isoforms with the lysine in the RKR triad mutated remain sensitive to pH. (A and B) Representative current traces from WT ROMK2 (A) and ROMK2-K61M (B) from inside-out giant-patches of oocytes showing pH responses to step acidification of the cytosolic face solution. (C) pH dose–response curves are shown for WT ROMK (open symbols) and K-mutant (solid symbols) channels.
