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Loss of Ik leads to a somatotrophin-deficiency phenotype. At 3 weeks of age, circulating hormone levels measured by specific ELISA show a marked reduction in the GH-target hormone, IGF-I (Left), in KO mice; there is no significant difference in levels of serum PRL (Center) or TSH (Right). Values represent means ± SEM. n, the number of animals in each group; ∗, P < 0.05.
