Fig. 2.

Growth hormone treatment, but not lymphocyte reconstitution, restores normal growth of Ik-deficient mice. (a) Systemic GH administration increases circulating IGF-I levels (Left) and rate of weight gain (Right) in Ik-deficient mice. Ik-null mice experienced a 35% gain in weight with this treatment. (b) In contrast, lymphocyte reconstitution with WT marrow cells at birth failed to increase IGF-I levels (Left) and did not significantly alter growth (Right) compared with vehicle-treated KO mice at 5 weeks after injection. All values represent means ± SEM. ∗, P < 0.05.