Fig. 2.

Changes in gene expression elicited by loss of α-catenin. (A) mRNAs in five relevant categories that scored by microarray analyses as up-regulated or down-regulated in E18.5 cKO vs. WT epidermis. Numbers in parentheses correspond to fold change. Asterisks refer to mRNAs not expressed by keratinocytes. EMT, epithelial-mesenchymal transition. (B) Real-time PCR of mRNAs from E18.5 epidermis (epid), FACS-purified keratinocytes from epidermis (GFPepid), and primary keratinocytes (cult) cultured in low calcium medium to prevent intercellular adhesion. Fold change is relative to WT-epid (=1).