Table 2.

Gene expression changes in MCL with p53 aberrations

Gene symbol	Gene description	Location	Fold change	P value
p53 point mutations versus wild-type cases
XPC	Xeroderma pigmentosum, complementation group C	3p25	−1.40*	3.3 × 10−5
HRB2	HIV-1 rcv-binding protein 2	12q21.1	−1.45	7.3 × 10−5
PVT1	Pvt1 oncogene homolog, MYC activator (mouse)	8q24	−1.55	3.6 × 10−4
GBE1	Glucan (1,4-α-), branching enzyme 1	3p12.3	−1.27	5.8 × 10−4
STK38	Serine/threonine kinase 38	6p21	−1.47	7.6 × 10−4
GLIPR1	GLI pathogenesis-related 1 (glioma)	12q21.1	−1.41	8.2 × 10−4
CLK2	CDC-like kinase 2	1q21	−1.24	8.7 × 10−4
SPAP1	SH2 domain containing phosphatase anchor protein 1	1q21	−1.35	9.1 × 10−4
PTPN22	Protein tyrosine phosphatase, nonreceptor type 22	1p13.3-p13.1	−1.47	9.5 × 10−4
MEF2B	MADS box transcription enhancer factor 2	19p12	−1.68	9.9 × 10−4
BIRC5	Baculoviral IAP repeat-containing 5 (survivin)	17q25	1.68	3.2 × 10−4
MTHFD2	Methylenetetrahydrofolate dehydrogenase 2	2p13.1	1.39	4.6 × 10−4
KIT	V-kit Hardy–Zuckerman 4 feline sarcoma oncogene	4q11-q12	1.95	4.6 × 10−4
CASP7	Caspase 7, apoptosis-related cysteine protease	10q25	1.42	4.7 × 10−4
CEP2	Centrosomal protein 2	20q11.22-q12	1.44	5.3 × 10−4
HBZ	Hemoglobin, ζ	16p13.3	1.93	5.7 × 10−4
PLK1	Polo-like kinase 1 (Drosophila)	16p12.1	1.62	6.9 × 10−4
DAD1	Defender against cell death 1	14q11-q12	1.18	8.2 × 10−4
JUP	Junction plakoglobin	17q21	1.77	8.7 × 10−4
ASPM	Asp (abnormal spindle)-like	1q31	1.51	9.8 × 10−4
p53 genomic deletions versus wild-type cases
MAP2K4†	Mitogen-activated protein kinase kinase 4	17p11.2	−1.70	2.0 × 10−7
SPAG7†	Sperm-associated antigen 7	17p13.2	−1.63	1.2 × 10−5
ATP2A3†	ATPase, Ca++ transporting, ubiquitous	17p13.3	−1.61	1.2 × 10−4
TAL2	T-cell acute lymphocytic leukemia 2	9q32	−1.47	1.4 × 10−4
DVL2†	Dishevelled, dsh homolog 2 (Drosophila)	17p13.2	−1.60	1.8 × 10−4
XPC	Xeroderma pigmentosum, complementation group C	3p25	−1.44	1.8 × 10−4
NFATC2	Nuclear factor of activated T cells	20q13.2–3	−1.41	2.6 × 10−4
DPH2L1†	Candidate tumor suppressor in ovarian cancer 2	17p13.3	−1.41	3.9 × 10−4
CENTB1†	Centaurin, β 1	17p13.1	−1.47	5.3 × 10−4
ITGAE†	Integrin, α E	17p13	−1.39	6.4 × 10−4
ZFP161	Zinc finger protein 161 homolog (mouse)	18pter-p11.2	−1.38	7.1 × 10−4
RGS13	Regulator of G protein signaling 13	1q31.2	−2.73	7.7 × 10−4
TERT	Telomerase reverse transcriptase	5p15.33	−1.39	7.8 × 10−4
SELL	Selectin L (lymphocyte adhesion molecule 1)	1q23-q25	−2.10	8.3 × 10−4
POLD1	Polymerase, delta 1, catalytic subunit 125 kDa	19q13.3	1.52	6.5 × 10−5
CDT1	DNA replication factor	16q24.3	1.62	1.2 × 10−4
PPP5C	Protein phosphatase 5, catalytic subunit	19q13.3	1.43	1.6 × 10−4
PLK1	Polo-like kinase 1 (Drosophila)	16p12.1	2.00	7.5 × 10−4
PTP4A3	Protein tyrosine phosphatase type IVA, member 3	8q24.3	1.64	4.0 × 10−4
BIRC5	Baculoviral IAP repeat-containing 5 (survivin)	17q25	1.90	5.1 × 10−4
UQCRB	Ubiquinol-cytochrome c reductase-binding protein	8q22	1.39	6.1 × 10−4
CKS2	CDC28 protein kinase regulatory subunit 2	9q22	1.61*	8.0 × 10−4
MYC	V-myc myelocytomatosis viral oncogene homolog	8q24.12-.13	2.03	7.4 × 10−4
PRKAR1B	Protein kinase, cAMP-dependent, reg., type I, β	7pter-p22	1.32	8.3 × 10−4
HRAS	V-Ha-ras Harvey rat sarcoma viral oncogene	11p15.5	1.37	9.4 × 10−4
AKAP1	A kinase (PRKA) anchor protein 1	17q21-q23	1.45	9.6 × 10−4
HN1	Hematological and neurological expressed 1	17q25.1	1.62	9.9 × 10−4

*Average of multiple values. The largest P value from random-variance t tests for multiple probe sets is provided.

^†Located in the 17p11–17p13 p53 genomic region.