Fig. 4.

The effect of ARA-S (10 mg/kg), Abn-CBD (20 mg/kg), and HU-210 (50 μg/kg) on LPS-induced plasma TNF-α levels in wild-type (n = 32), CB₁^−/− (n = 5), and CB₂^−/− (n = 4) mice. Basal levels of TNF-α were 30 ± 10, 39 ± 15, and 35 ± 13 pg/ml, and LPS-stimulated levels were 3,407 ± 197, 3,642 ± 326, and 6,877 ± 857 pg/ml in the three groups, respectively. Significant difference from vehicle-treated values is indicated by ∗ (P < 0.05) and ∗∗ (P < 0.001).