Fig. 4.

Neutralization of cell culture-produced virus infectivity by antibody to HCV or CD81. (A) Neutralization of H77-S (Upper) and JFH-1 (Lower) viruses by paired preinfection (▵) or after seroconversion (▴) sera from three individuals sustaining infection with genotype 1a HCV. The horizontal lines and shaded zones indicate the mean and range of infectious foci obtained with each viral inoculum in the absence of any serum. (B) Anti-CD81 Ab, added to virus before its inoculation onto Huh-7.5 cells, prevents infection with either H77-S (Left) or JFH-1 (Right) inocula.