Table 1.
Growth kinetics of normal and hTERT SMC from elderly donors and 17yo donor
| Vascular cell source | Days in culture | Total PDs | Average PDs/day | Average PD time, days |
|---|---|---|---|---|
| 17yo normal | 84 | 41 | 0.490 | 2.0 |
| 17yo hTERT | 118 | 84 | 0.714 | 1.4 |
| 57yo normal | 61 | 24 | 0.415 | 2.5 |
| 57yo hTERT | 181 | 56 | 0.304 | 3.2 |
| 65yo normal | 51 | 15 | 0.294 | 2.6 |
| 65yo hTERT | 307 | 62 | 0.202 | 4.9 |
| 81yo normal | 22 | 4 | 0.164 | 2.5 |
| 81yo hTERT | 212 | 52 | 0.245 | 2.8 |
| 85yo normal | 51 | 15 | 0.294 | 3.4 |
| 85yo hTERT | 342 | 100 | 0.292 | 3.6 |
All hTERT cultures were arbitrarily stopped as they showed no signs of senescence. Population doubling times for hTERT SMC were significantly slower than corresponding control SMC populations.