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. 2006 Feb 21;103(9):3422–3427. doi: 10.1073/pnas.0507710103

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© 2006 by The National Academy of Sciences of the USA

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Fig. 2. — TASK channel inhibition involves Gαq. (A) Normalized pH-sensitive conductance in cells transfected with TASK-3 and constitutively active G protein α subunits or Gβ1γ2. (Left) Only Gαq* or Gα11* inhibited TASK-3 currents. (Center) Gαq* did not decrease conductance in cells expressing a TASK-3/TREK chimeric channel that is not receptor modulated. (Right) The PLC-inactive Gαq*(AA) mutant was as effective as Gαq* at inhibiting TASK-3 (∗, P < 0.05 by ANOVA, n ≥ 6 per group). (B) The effect of bath acidification and TRH was determined in Fq/11 fibroblasts from Gαq/11 knockout mice transfected with the indicated constructs. (C) TRH inhibition of pH-sensitive TASK conductance in Fq/11 cells was rescued by expression of either Gαq or Gαq(AA) (∗, P < 0.05 by ANOVA, n ≥ 6 per group).