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Mdm2 is essential for neuronal progenitors survival. Analyses are of Nes-Cre p53lsl/− mdm2+/− versus mdm2−/− embryos (carrying wild-type mdm4 alleles). External views and H&E staining are of embryonic-day-12.5 embryos. (Magnification: ×0.5.) Also shown is ISEL staining and IHC for p53 and casp-3* in the neuroepithelium of the forebrain region of embryonic-day-12.5 embryos. (Magnification: ×20.) The arrowhead indicates obvious head developmental defect in the forebrain area.
