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. 2006 Feb 21;103(9):3226–3231. doi: 10.1073/pnas.0508500103

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© 2006 by The National Academy of Sciences of the USA

Freely available online through the PNAS open access option.

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Fig. 2. — Proencephaly in mice lacking Mdm4 in the CNS. (A) Specific recombination of the Mdm4^FX allele in E14.5 Mdm4^FX/FX Nes-Cre embryos. Numbers label Mdm4 exons (boxes). The closed circle is an frt site, and diamonds are loxP sites. The triangles are PCR primers used for detection of the recombination event. F4 and E2re amplify the Mdm4 conditional allele. F4 and In2re2 amplify the Mdm4 allele (Δ2) after recombination. Hematoxylin/eosin-stained sagittal (B) and coronal (C) sections of embryos at E18.5. All embryos have the Nes-Cre transgene. M4^FX/+, Mdm4^FX/+, M4^FX/FX, and Mdm4^FX/FX; M, 1-kb-plus marker; In, intestine; Lu, Lung; Li, Liver; Tl, Tail; Br, Brain; H, Heart; C, cortex; V, ventricle; and LV, lateral ventricle.