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Apoptosis and cell cycle arrest in embryos lacking Mdm2 and Mdm4 in the CNS. BrdUrd (A), TUNEL (B), and p21 immunohistochemical staining (C) of CNS sections of E10.5 embryos. (D) Real-time RT-PCR was performed by using RNA from heads of E10.5 wild-type (Ctl), Mdm2FM/FM Nes-Cre (M2), Mdm4FX/FX Nes-Cre (M4), and Mdm2FM/FM Mdm4FX/FX Nes-Cre (DN) embryos. V, ventricle. (Scale bars, 100 μm.)
