Fig. 2.

Effect of the soluble guanylate cyclase inhibitor ODQ on cGMP levels (Upper) and inhibition of platelet adhesion (Lower) by SNP at 15 (A) and 60 (B) min. Nonactivated or thrombin (50 milliunits/ml)-activated platelets (1.2 × 10⁸ platelets/ml) were incubated with SNP (0.1 and 1 mM) for 15 or 60 min in the presence or absence of ODQ (10 μM). Dashed lines represent basal levels of cGMP. The results are shown as the means ± SEM (n = 3). ∗, P < 0.05, ∗∗, P < 0.01, and ∗∗∗, P < 0.001, compared with the experiments in the absence of ODQ.