Table 1.

Metabolic parameters of db/db mice

Parameter	Vehicle	GW501516
Weight gain, g	5.91 ± 0.56	6.06 ± 0.46
Liver/body weight	0.058 ± 0.001	0.072 ± 0.003**
Fat/body weight	0.039 ± 0.001	0.039 ± 0.002
Serum lipids
TG, mg/dl	300.42 ± 37.58	272.61 ± 34.17
Free fatty acid, mEq/liter	0.48 ± 0.05	0.46 ± 0.04
Cholesterol, mg/dl	123.58 ± 6.69	164.23 ± 9.69**
HDL-c, mg/dl	68.20 ± 3.97	94.21 ± 6.05**
Fasting glucose, mg/dl	594.4 ± 45.6	396.0 ± 41.4*
	298.0 ± 27.1†	229.3 ± 17.0†*
Fasting insulin, ng/ml	27.24 ± 4.48	20.91 ± 2.94
	23.08 ± 6.65†	7.38 ± 1.82†*
Acrp30, mg/ml	7.20 ± 0.73	9.00 ± 1.08

Mice were 10 weeks old at the start of the 2-week drug treatment. HDL-c, high-density lipoprotein cholesterol.

^†8-week-old mice at the start of the 2-week drug treatment.

*, P < 0.05;

**, P < 0.005.