Fig. 3.

The network of interactions in SOD1. (a) A representation of the graph of the SOD1 dimer. Each node corresponds to a residue, and an edge exists between the nodes if they form a van der Waals contact. The dimer interface residues are colored blue, and the residues in the metal-binding sites are colored red. An example minimal path from L8 to the dimer interface and to the metal-binding sites is shown in green. The β-plug residues are colored yellow. (b and c) The distribution of normalized average minimal paths from a given residue to all other residues in the protein (b) and the betweenness of each residue (c).