Figure 4.

Blocking mGluR2/3 prevents the capacity of N-acetylcysteine to inhibit cocaine-induced reinstatement. Each rat was given injections of either N-acetylcysteine (60 mg/kg, s.c.) or saline 4 h before a cocaine injection (10 mg/kg, i.p.). In addition, rats were given injections once every hour after the injection of N-acetylcysteine or saline with either saline or the mGluR2/3 antagonist LY341495 (1 mg/kg, i.p.) before the cocaine priming injection. The data are shown as the mean ± SEM total number of active lever presses during the 120 min after a cocaine-priming injection (n > 5 for each treatment). ^*p < 0.05, compared with control (first bar on the left) using a one-way ANOVA followed by a Dunnett's test.