TABLE 1.
Risk Factors for Neurocognitive Decline After CEA. Logistic Regression
| Injured | Uninjured | OR | 95% CI | P | |
|---|---|---|---|---|---|
| Patients (n) | 18 (26%) | 51 (74%) | … | … | … |
| Age | 75.2±5.3 | 69.2±8.5 | 1.12# | (1.02, 1.24) | 0.02* |
| Male gender | 9 (50%) | 32 (63%) | … | … | … |
| Obesity* | 2 (11%) | 9 (18%) | … | … | … |
| Smoking | 12 (67%) | 32 (63%) | … | … | … |
| Hypertension† | 11 (61%) | 39 (76%) | … | … | … |
| Diabetes mellitus | 4 (28%) | 11 (22%) | … | … | … |
| Hypercholesterolemia‡ | 11 (61%) | 28 (55%) | … | … | … |
| Statin medication | 11 (61%) | 20 (40%) | … | … | … |
| Previous myocardial infarction | 4 (22%) | 18 (35%) | … | … | … |
| Previous contralateral CEA | 0 (0%) | 5 (10%) | … | … | … |
| Right operative side | 10 (55%) | 20 (39%) | … | … | … |
| Duration of surgery | 143.4±31.6 | 147.9±47.1 | … | … | … |
| Duration of cross-clamp | 39.8±15.7 | 43.3±19.8 | … | … | … |
| Shunt placement | 1 (6%) | 0 (0%) | … | … | … |
| WBC count | 7.96±1.71 | 6.96±2.19 | … | … | … |
| Neutrophil count | 5.13±1.44 | 4.33±1.54 | 1.78** | (0.97, 3.27) | 0.06 |
| Monocyte count | 0.70±0.19 | 0.52±0.18 | 2.37** | (1.21, 4.62) | 0.01* |
| Lymphocyte count | 1.84±0.57 | 1.86±0.95 | … | … | … |
*
Obesity=body mass index ≥30
†
hypertension=systolic blood pressure >140 and/or use of antihypertensives
‡
hypercholesterolemia=cholesterol >200 and/or use of anticholesterol medication; odds ratios, CIs, and P values presented apply to multivariate logistic regression
#
Age odds ratio: per year increase
**
monocyte/neutrophil ORs: per SD increase in cell count (monocyte: 0.20 cells/nL; neutrophils: 1.5 cells/nL); no other variables achieved criteria for inclusion in multivariate analysis; continuous data presented as mean±SD.