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. Author manuscript; available in PMC: 2006 Mar 27.
Published in final edited form as: Biochem Soc Trans. 2005 Dec;33(Pt 6):1385–1389. doi: 10.1042/BST20051385

Figure 3.

Figure 3

Mechanisms of mitochondrial-dependent redox signalling OxLDL, electrophilic lipids or lysoPC induce O2•− generation in mitochondria that may then be converted into H2O2. OxLDL also activates NOS and increases production of NO; in the presence of available O2•−, oxLDL may contribute to peroxynitrite formation. In addition, lysoPC can elevate intracellular calcium levels. Furthermore, ROS, RNS and electrophilic lipids contribute to the post-translational modification of protein thiols (protein-SH) to form protein-S-X. Moreover, it is postulated that oxidative stress increases the intracellular pool of electrophilic lipids.