Table 1.
Hemodynamic variables in rat lungs isolated 12 h after surgical interventions
| Hemodynamic variable | Time (minutes) | ||||
| 0 | 30 | 60 | 90 | 120 | |
| PPA, cmH2O | |||||
| Sham | 26.0 ± 3.1 | 24.6 ± 3.1 | 24.6 ± 2.7 | 26.0 ± 3.0 | 26.0 ± 3.0 |
| CLP | 21.9 ± 1.5 | 23.2 ± 1.3 | 23.2 ± 1.6 | 24.6 ± 2.3 | |
| CLP+Tezo | 24.6 ± 0.9 | 23.2 ± 0.9 | 23.2 ± 1.1 | 21.9 ± 1.2 | 24.6 ± 1.7 |
| PLA, cmH2O | |||||
| Sham | 14.6 ± 0.6 | 14.7 ± 0.6 | 14.9 ± 0.9 | 15.6 ± 0.9 | 14.9 ± 0.9 |
| CLP | 13.8 ± 0.4 | 13.8 ± 0.4 | 13.8 ± 0.4 | 13.4 ± 0.8 | |
| CLP+Tezo | 14.9 ± 0.4 | 14.9 ± 0.4 | 14.7 ± 0.4 | 15.4 ± 0.4 | 15.2 ± 0.4 |
| RT, cmH2O/ml/min | |||||
| Sham | 0.89 ± 0.1 | 0.80 ± 0.1 | 0.83 ± 0.1 | 0.84 ± 0.1 | 0.82 ± 0.1 |
| CLP | 0.57 ± 0.1 | 0.65 ± 0.1 | 0.67 ± 0.1 | 0.67 ± 0.1 | |
| CLP+Tezo | 0.75 ± 0.0 | 0.67 ± 0.0 | 0.67 ± 0.1 | 0.67 ± 0.1 | 0.71 ± 0.1 |
| ΔPmv, cmH2O | |||||
| Sham | 7.2 ± 0.2 | 7.2 ± 0.3 | 7.5 ± 0.3 | 7.2 ± 0.3 | 7.5 ± 0.3 |
| CLP | 6.7 ± 0.5 | 6.5 ± 0.4 | 6.4 ± 0.4 | 6.5 ± 0.6 | |
| CLP+Tezo | 7.6 ± 0.4 | 7.6 ± 0.4 | 7.5 ± 0.4 | 8.0 ± 0.4 | 7.6 ± 0.5 |
Data are presented as mean ± SEM. Sham, sham-operated group (n = 5); CLP, cecum ligation and puncture group (n = 7); CLP+Tezo, cecum ligation and puncture + tezosentan group (n = 7). PLA, left atrial pressure; PPA, pulmonary artery pressure; ΔPmv, difference between pulmonary microvascular pressure determined prior to and during a standardized elevation of PLA; RT, total vascular resistance.