Table 2.
Hemodynamic variables in blood perfused lungs isolated from healthy rats
| Hemodynamic variable | Time (minutes) | ||||
| 0 | 30 | 60 | 90 | 120 | |
| PPA, cmH2O | |||||
| Control | 22.0 ± 1.6 | 21.7 ± 1.7 | 22.4 ± 2.1 | 24.1 ± 1.9 | 23.4 ± 2.0 |
| ET-1 | 19.7 ± 1.0 | 18.7 ± 1.3 | 18.9 ± 1.7 | 17.5 ± 2.0 | |
| ET-1+Tezo | 21.7 ± 0.4 | 21.0 ± 1.6 | 22.6 ± 1.2 | 19.8 ± 1.3 | 22.6 ± 1.6 |
| PLA, cmH2O | |||||
| Control | 14.3 ± 0.8 | 14.6 ± 0.9 | 14.6 ± 0.9 | 14.9 ± 0.8 | 14.9 ± 0.8 |
| ET-1 | 13.1 ± 0.8 | 13.1 ± 0.9 | 13.1 ± 0.9 | 14.7 ± 1.2 | |
| ET-1+Tezo | 13.1 ± 0.8 | 13.1 ± 0.9 | 12.3 ± 0.8 | 10.9 ± 0.8 | 12.4 ± 0.8 |
| RT, cmH2O/ml/min | |||||
| Control | 0.58 ± 0.1 | 0.54 ± 0.1 | 0.60 ± 0.1 | 0.69 ± 0.1 | 0.72 ± 0.1 |
| ET-1 | 0.49 ± 0.1 | 0.42 ± 0.1 | 0.43 ± 0.1 | 0.20 ± 0.1 | |
| ET-1+Tezo | 0.80 ± 0.1 | 0.75 ± 0.1 | 0.78 ± 0.0 | 0.68 ± 0.1 | 0.78 ± 0.1 |
| ΔPmv, cmH2O | |||||
| Control | 6.5 ± 0.4 | 6.5 ± 0.4 | 6.5 ± 0.4 | 6.5 ± 0.4 | 6.9 ± 0.4 |
| ET-1 | 6.9 ± 0.4 | 6.9 ± 0.4 | 6.7 ± 0.4 | 6.9 ± 0.5 | |
| ET-1+Tezo | 7.2 ± 0.4 | 7.2 ± 0.4 | 7.2 ± 0.4 | 7.2 ± 0.4 | 7.3 ± 0.4 |
Data are presented as mean ± SEM. Control, control group (n = 8); ET-1, endothelin-1 group (n = 7); ET-1+Tezo, endothelin-1+tezosentan group (n = 7). PLA, left atrium pressure; PPA, pulmonary artery pressure; ΔPmv, difference between pulmonary microvascular pressure determined prior to and during a standardized elevation of PLA (7.9 cmH2O); RT, total vascular resistance.