Table 2.
Hemodynamic responses in baboons infused with live Escherichia coli and treated with placebo or anti-L-selectin antibody
| Time (hours) | |||||||||||
| -0.5 | 0 | 1 | 2 | 4 | 6 | 10 | 24 | 32 | 48 | 72 | |
| Heart rate (beats/minute) | |||||||||||
| Placebo | 124 ± 3 | 125 ± 3 | 156 ± 9 | 171 ± 7 | 170 ± 5 | 160 ± 5 | 141 ± 7 | 142 ± 6 | 138 ± 9 | 139 ± 5 | 151 ± 11 |
| L-SEL-Ab | 122 ± 5 | 121 ± 4 | 160 ± 9 | 177 ± 7 | 165 ± 3 | 168 ± 6 | 151 ± 5 | 142 ± 15 | 141 ± 14 | 143 ± 10 | 158 ± 10 |
| MAP (mmHg) | |||||||||||
| Placebo | 113 ± 6 | 122 ± 3 | 102 ± 8 | 72 ± 5 | 103 ± 5 | 117 ± 6 | 95 ± 9 | 75 ± 11 | 75 ± 6 | 65 ± 11 | 70 ± 6 |
| L-SEL-Ab | 119 ± 4 | 122 ± 3 | 104 ± 6 | 72 ± 5 | 97 ± 5 | 111 ± 6 | 85 ± 10 | 51 ± 8 | 51 ± 7 | 61 ± 12 | 79 ± 8 |
| CO (l/minute) | |||||||||||
| Placebo | 3.1 ± 0.2 | 3.2 ± 0.2 | 4.3 ± 0.4 | 4.6 ± 0.4 | 4.4 ± 0.4 | 4.2 ± 0.4 | 2.5 ± 0.2 | 3.5 ± 0.4 | 4.2 ± 0.3 | 3.6 ± 0.3 | 3.7 ± 0.2 |
| L-SEL-Ab | 3.1 ± 3.1 | 3.1 ± 3.1 | 4.8 ± 4.8 | 5.5 ± 5.5 | 4.8 ± 4.8 | 4.6 ± 4.6 | 2.5 ± 2.5 | 3.0 ± 3.0 | 3.8 ± 3.8 | 3.6 ± 3.6 | 3.8 ± 3.8 |
| MPAP (mmHg) | |||||||||||
| Placebo | 13 ± 1 | 14 ± 1 | 14 ± 1 | 13 ± 1 | 14 ± 2 | 18 ± 2 | 17 ± 3 | 17 ± 2 | 18 ± 3 | 15 ± 1 | 16 ± 3 |
| L-SEL-Ab | 13 ± 1 | 13 ± 1 | 13 ± 1 | 14 ± 1 | 14 ± 1 | 18 ± 1 | 16 ± 1 | 16 ± 2 | 16 ± 1 | 16 ± 1 | 15 ± 3 |
| PWP (mmHg) | |||||||||||
| Placebo | 3.5 ± 0.4 | 3.6 ± 0.5 | 4.4 ± 0.8 | 4.5 ± 1.0 | 4.8 ± 0.9 | 5.4 ± 0.8 | 1.4 ± 0.6 | 1.5 ± 0.5 | 3.5 ± 0.3 | 2.0 ± 0.7 | 1.5 ± 1.0 |
| L-SEL-Ab | 4.6 ± 0.7 | 4.5 ± 0.6 | 4.8 ± 0.6 | 5.5 ± 0.9 | 4.6 ± 0.8 | 4.9 ± 0.8 | 2.9 ± 0.6 | 2.8 ± 0.4 | 2.7 ± 0.4 | 3.6 ± 0.9 | 3.7 ± 0.3 |
| PVR (dyn s cm-5) | |||||||||||
| Placebo | 264 ± 21 | 258 ± 16 | 180 ± 11 | 160 ± 17 | 180 ± 20 | 265 ± 41 | 542 ± 112 | 399 ± 80 | 285 ± 58 | 292 ± 22 | 301 ± 78 |
| L-SEL-Ab | 220 ± 20 | 223 ± 18 | 142 ± 22 | 124 ± 15 | 162 ± 21 | 243 ± 30 | 441 ± 58 | 362 ± 50 | 296 ± 27 | 267 ± 25 | 279 ± 70 |
| arterial pO2 (mmHg) | |||||||||||
| Placebo | 100.4 ± 6.8 | 101.5 ± 6.9 | 97.7 ± 5.2 | 104.8 ± 4.5 | 105.0 ± 4.3 | 100.2 ± 4.3 | 88.2 ± 2.5 | 84.7 ± 4.6 | 76.7 ± 6.4 | 73.1 ± 7.0 | 63.4 ± 6.5 |
| L-SEL-Ab | 101.9 ± 5.9 | 102.2 ± 4.4 | 105.0 ± 6.3 | 109.9 ± 4.0 | 105.9 ± 5.7 | 103.6 ± 6.0 | 91.0 ± 5.7 | 89.1 ± 5.4 | 82.2 ± 3.5 | 88.7 ± 7.5 | 77.6 ± 8.3 |
| arterial pCO2 (mmHg) | |||||||||||
| Placebo | 48.8 ± 1.1 | 46.4 ± 1.0 | 45.0 ± 1.2 | 41.1 ± 1.2 | 34.6 ± 2.3 | 36.3 ± 0.9 | 33.2 ± 1.1 | 33.9 ± 1.9 | 34.1 ± 2.4 | 40.5 ± 3.2 | 45.7 ± 3.3 |
| L-SEL-Ab | 43.7 ± 1.5 | 43.1 ± 1.5 | 40.9 ± 0.4 | 39.1 ± 0.9 | 35.0 ± 1.7 | 34.5 ± 0.9 | 28.9 ± 2.3 | 31.5 ± 2.3 | 33.0 ± 3.4 | 35.3 ± 4.3 | 40.7 ± 6.1 |
arterial pCO2, arterial partial carbondioxide pressure; arterial pO2, arterial partial oxygen pressure; CO, cardiac output; L-SEL-Ab, anti-L-selectin antibody; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; PWP, pulmonary arterial wedge pressure; PVR, peripheral vascular resistance.