Table 4.
Fluid infusion requirements
| Time (hours) | |||||||||||
| -0.5 | 0 | 1 | 2 | 4 | 6 | 10 | 24 | 32 | 48 | 72 | |
| Ringer (ml/kg BW) | |||||||||||
| Placebo | 1 ± 0 | 7 ± 0 | 21 ± 2 | 40 ± 4 | 92 ± 4 | 134 ± 6 | 135 ± 6 | 159 ± 7 | 186 ± 11 | 223 ± 13 | 250 ± 19 |
| L-SEL-Ab | 1 ± 0 | 7 ± 0 | 20 ± 2 | 38 ± 4 | 90 ± 6 | 130 ± 9 | 131 ± 10 | 157 ± 11 | 189 ± 16 | 204 ± 9 | 219 ± 16 |
| Hematocrit (%) | |||||||||||
| Placebo | 42.1 ± 1.3 | 40.3 ± 1.1 | 37.8 ± 1.2 | 35.7 ± 1.4 | 36.4 ± 1.6 | 36.6 ± 1.4 | 40.8 ± 1.5 | 35.4 ± 2.3 | 29.1 ± 2.0 | 27.5 ± 1.6 | 26.0 ± 2.5 |
| L-SEL-Ab | 40.7 ± 1.6 | 38.6 ± 1.7 | 37.8 ± 1.5 | 34.8 ± 1.3 | 35.5 ± 1.4 | 36.5 ± 1.5 | 40.4 ± 1.8 | 34.3 ± 1.5 | 31.4 ± 1.6 | 29.7 ± 1.2 | 28.6 ± 2.2 |
| Protein (g/100 ml) | |||||||||||
| Placebo | 6.5 ± 0.2 | 6.1 ± 0.1 | 5.3 ± 0.2 | 4.5 ± 0.2 | 4.2 ± 0.1 | 4.1 ± 0.1 | 4.8 ± 0.1 | 4.6 ± 0.1 | 4.4 ± 0.2 | 4.1 ± 0.3 | 4.5 ± 0.4 |
| L-SEL-Ab | 6.0 ± 0.2 | 5.7 ± 0.2 | 5.0 ± 0.1 | 4.1 ± 0.1 | 4.0 ± 0.1 | 4.0 ± 0.2 | 4.5 ± 0.2 | 4.1 ± 0.2 | 4.0 ± 0.2 | 4.0 ± 0.3 | 4.4 ± 0.4 |
Accumulation amount of Ringer's solution over time, hematocrit and total plasma protein concentration in baboons infused with live Escherichia coli and treated with either placebo or anti-L-selectin antibody (L-SEL-Ab). BW = body weight.