Table 5.

Kidney and liver function

	Time (hours)
	-0.5	0	1	2	4	6	10	24	32	48	72
Creatinine (μmol/l)
Placebo	86 ± 3	81 ± 5	78 ± 6	80 ± 6	93 ± 6	97 ± 11	133 ± 18	200 ± 48	189 ± 73	112 ± 10	96 ± 7
L-SEL-Ab	105 ± 6	96 ± 7	88 ± 7	93 ± 5	104 ± 6	109 ± 7	145 ± 16	240 ± 42	276 ± 65	226 ± 90a	121 ± 12
Urine output (ml/h)
Placebo	nd	43.8 ± 11.0	31.9 ± 9.3	63.75 ± 29.0	111.3 ± 95.8	124.4 ± 34.3	84.4 ± 17.5	87.1 ± 27.2	80.8 ± 25.0	69.0 ± 12.6	nd
L-SEL-Ab	nd	36.88 ± 11.1	38.1 ± 12.3	66.9 ± 26.4	161.9 ± 42.0	122.5 ± 41.1	94.4 ± 25.6	79.4 ± 16.4	55.0 ± 7.2	72.0 ± 7.3	nd
BUN (mg/dl)
Placebo	12.7 ± 1.2	12.1 ± 1.3	13.2 ± 1.3	12.2 ± 1.4	11.7 ± 1.4	11.9 ± 1.2	17.9 ± 2.0	30.8 ± 1.8	34.1 ± 4.3	38.0 ± 7.3	30.5 ± 4.3
L-SEL-Ab	13.7 ± 2.2	13.6 ± 2.2	11.6 ± 1.8	12.8 ± 2.1	11.9 ± 2.2	12.4 ± 2.0	16.4 ± 2.0	32.7 ± 2.5	39.7 ± 3.4	41.9 ± 6.3	31.6 ± 4.1
ALT (U/l)
Placebo	12 ± 3	12 ± 2	9 ± 2	8 ± 2	25 ± 11	46 ± 20	78 ± 27	112 ± 21	93 ± 24	68 ± 12	71 ± 18
L-SEL-Ab	13 ± 2	10 ± 2	7 ± 0	7 ± 2	13 ± 4	16 ± 5	37 ± 13	93 ± 35	110 ± 28	100 ± 26	100 ± 30

Organ function in baboons infused with live Escherichia coli and treated with either placebo or anti-L-selectin antibody. ^ap = 0.047.

ALT, alanine transferase; BUN, blood urea nitrogen; L-SEL-Ab, anti-L-selectin antibody; nd, not done.