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. Author manuscript; available in PMC: 2006 Mar 27.
Published in final edited form as: J Immunol. 2005 Aug 15;175(4):2449–2458. doi: 10.4049/jimmunol.175.4.2449

FIGURE 9.

FIGURE 9

Model of early signal transduction in T cells. Upon TCR stimulation, activated ZAP-70 directly phosphorylates of LAT tyrosine 191 and indirectly mediates the phosphorylation of LAT tyrosine 132 via a mechanism that occurs with slower kinetics than LAT tyrosine 191. Once phosphorylated, LAT associates with several proteins, including PLC-γ1 and the SLP-76-Vav-Itk complex. The recruitment of these proteins to LAT results in the phosphorylation of tyrosine 783 on PLC-γ1, leading to the activation of this protein.