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. Author manuscript; available in PMC: 2006 Mar 27.
Published in final edited form as: J Phys Chem B. 2005 Dec 29;109(51):24517–24525. doi: 10.1021/jp0534232

FIGURE 7.

FIGURE 7

Proposed scheme for the formation of symmetric/asymmetric complex of GroEL/GroES with ADP/AlFx. (A). When GroES is added first, GroES can only bind after adding ADP/AlFx, and the binding affinity of ADP/AlFx to the trans ring may be reduced because of GroES binding to the cis ring. This prevents the formation of the symmetric complex. (B). When ADP/AlFx is added first (before GroES), hindered MDH binding to the GroEL can be explained by the formation of the symmetric football complex.