Table 3.
Proteins that physically interact with AP-2 transcription factors
| Protein | Description | Domain of AP-2 proteins that interacts* | Function of interaction | Reference |
| APC | Adenomatous polyposis coli tumor suppressor | Basic region | Inhibition of β-catenin/TCF/LEF-dependent transcription | [16] |
| CITED2 | Coactivator | DD | Transcriptional activation | [69] |
| CITED4 | Coactivator | n.d. | Transcriptional activation | [70] |
| CDP | CCAAT displacement protein | DBD, DD | Repression of the hamster histone H3.2 promoter | [71] |
| DEK | Oncoprotein, chromatin remodeling | n.d. | Transcriptional activation | [72] |
| E1A | Transforming protein of adenovirus | DBD, DD | Repression of AP-2 target genes | [73] |
| c-Myc | Oncoprotein | Carboxyl terminus | Impairment of Myc/Max DNA-binding and transactivation | [14] |
| PARP | PolyADP-ribose polymerase | Carboxyl terminus | Transcriptional activation | [74] |
| PAX-6 | Transcription factor | n.d. | Stimulation of gelatinase B activation | [75] |
| PC4 | Coactivator | Transcriptional activation | [24] | |
| P300/CBP | Coactivator | Amino terminus | Transcriptional activation | [69] |
| p53 | Tumor suppressor | n.d. | Augmentation of p53-dependent transcription | [76] |
| RAP74 | Subunit of transcription factor TFIIF | Central region containing DBD | Unknown | [74] |
| Rb | Retinoblastoma tumor suppressor | Amino terminus† | Repression of the hamster histone H3.2 promoter; transcriptional activation of the E-cadherin gene | [77,78] |
| SP1 | Transcription factor | Basic region | Transcriptional activation of the ovine CYP11A1 gene | [79] |
| SV40T | Transforming protein of SV40 virus | n.d. | Blocks DNA binding of AP-2 protein | [12] |
| UBC9 | E2-conjugating enzyme | DBD, DD | Sumoylation | [80] |
| WWOX | Tumor suppressor | Amino terminus PY motif | Cytoplasmic localization PPPY motif | [17] |
| YB-1 | Transcription factor | n.d. | Stimulation of gelatinase A transcription | [81] |
| YY1 | Transcription factor | DBD, DD | Stimulation of the hamster histone H3.2 promoter | [82] |
*Abbreviations: DBD, DNA-binding domain; DD, dimerization domain; n.d., not determined. †It is currently not entirely clear whether Rb binds AP-2 only via the amino terminus [78], or whether the DNA-binding domain is also necessary [77].