Table 2.
Most consistently dysregulated non-chromosome 21 genes based on their p values from ANOVA and after 5% false discovery rate cut-off
| Gene name | Accession number | Chromosome number | p value (ANOVA) | Cerebrum | Cerebellum | Astrocyte | Heart | ||||
| Control | TS21 | Control | TS21 | Control | TS21 | Control | TS21 | ||||
| Hypermethylated in cancer 1 (HIC1) | NM_006497 | 17 | 2.33E-08 | 6.5 | 1.9 | 4.8 | 3.8 | 4.6 | 2.0 | 41.3 | 5.8 |
| Myomesin 1 (skelemin) (185 kDa) (MYOM1) | NM_003803 | 18 | 8.82E-08 | 37.8 | 23.3 | 45.0 | 52.6 | 13.6 | 9.8 | 930.1 | 1302.5 |
| Myoglobin (MB) | NM_005368 | 22 | 1.09E-07 | 103.5 | 85.5 | 90.2 | 142.8 | 72.9 | 61.1 | 7392.9 | 12099.8 |
| Calsequestrin 2 (cardiac muscle) (CASQ2) | NM_001232 | 1 | 1.56E-07 | 17.7 | 9.3 | 14.1 | 19.5 | 14.4 | 14.3 | 2341.5 | 3868.7 |
| Ras-related associated with diabetes (RRAD) | NM_004165 | 16 | 5.06E-06 | 4.5 | 4.2 | 13.3 | 9.8 | 45.8 | 36.6 | 1907.1 | 932.0 |
| Troponin I, cardiac (TNNI3) | NM_000363 | 19 | 5.90E-06 | 49.0 | 44.1 | 44.6 | 71.2 | 31.1 | 25.2 | 2942.4 | 4757.2 |
| Insulin-like growth factor binding protein 7 (IGFBP7) | NM_001553 | 4 | 1.12E-05 | 223.8 | 314.7 | 741.5 | 519.4 | 2418.6 | 4205.6 | 743.8 | 1137.2 |
| Actin, alpha 1, skeletal muscle (ACTA1) | NM_001100 | 1 | 1.20E-05 | 38.6 | 38.5 | 33.7 | 47.6 | 55.9 | 138.1 | 553.4 | 2310.0 |
| Calcineurin-binding protein calsarcin-1 (MYOZ2) | NM_016599 | 4 | 1.22E-05 | 4.9 | 6.3 | 7.6 | 20.2 | 4.7 | 3.0 | 1742.3 | 2592.5 |
| Teratocarcinoma-derived growth factor 1 (TDGF1) | NM_003212 | 3 | 1.95E-05 | 10.6 | 11.8 | 8.2 | 9.9 | 31.1 | 20.6 | 11.3 | 187.9 |
| Tenomodulin protein (TNMD) | NM_022144 | X | 2.24E-05 | 7.2 | 5.4 | 10.0 | 6.4 | 5.8 | 4.8 | 23.6 | 103.0 |
| Olfactory receptor, family 7, subfamily E, member 12 pseudogene (OR7E12P) | AA459867 | 13 | 2.51E-05 | 115.4 | 88.7 | 149.1 | 87.6 | 144.8 | 116.1 | 215.1 | 58.4 |
| Cardiac troponin T2 (TNNT2) | X79857 | 1 | 2.56E-05 | 47.4 | 39.9 | 47.4 | 45.7 | 44.6 | 32.6 | 3710.3 | 4965.9 |
| A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 (ADAMTS8) | NM_007037 | 11 | 3.21E-05 | 13.0 | 11.5 | 14.6 | 15.5 | 15.1 | 11.4 | 282.8 | 154.7 |
The average expression values are for the probe sets corresponding to the genes (from MAS5 software). TS21, trisomy 21.