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. 2005 Dec 30;6(13):R113. doi: 10.1186/gb-2005-6-13-r113

Figure 1.

Figure 1

Schematic representation of the two-step procedure for phylogenetic footprinting. In the data reduction step, regions conserved among closely related (mammalian) orthologs are selected. Subsequently, these strongly conserved sequences are combined with a more distant ortholog (for example, Fugu); this set of genes is then subjected to motif detection. Finally, significantly conserved blocks are identified using a threshold defined by a random analysis.