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Differential histopathology of primary septicemic plague produced by Pla+ and Pla− Y. pestis after fleabite transmission. Extracellular bacteria (green arrowheads) are widely dispersed in spleen (A and C) and liver (E) infected with wild-type Y. pestis, but are contained in granulomatous-like lesions surrounded by degrading host cells (yellow arrowheads) in spleen (B and D) and liver (F) infected with Pla− Y. pestis. (Magnification: A and B, ×4; C, ×600; D–F, ×400.)
