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Regions of apoE4 involved in causing neurotoxicity, translocation into the cytosol, and mitochondrial targeting. The receptor binding region (amino acids 136–150) plays a key role in translocation, as well as in binding to the LDL receptor and tau. The lipid binding region (amino acids 240–270) plays a role in translocation and mitochondrial localization, in addition to possessing lipid and Aβ binding.
