. 2005 Feb;4(1):37–44.

Table 2.

Population-level intervention effects (DALYs averted per year per one million population)

		World Bank Region
		Sub-Saharan	Latin America	Middle East	Europe	South	East Asia
		Africa	& Caribbean	& North Africa	& Central Asia	Asia	& Pacific
Total population (million)		640	502	482	462	1,242	1,827
	Coverage
Schizophrenia¹
Older (neuroleptic) antipsychotic drug	80%	149	219	214	254	177	231
Newer antipsychotic drug	80%	160	235	230	273	190	248
Older antipsychotic drug +	80%	254	373	364	353	300	392
psychosocial treatment	80%	254	373	364	353	300	392
Newer antipsychotic drug +	80%	261	383	373	364	308	403
psychosocial treatment	80%	261	383	373	364	308	403

Bipolar disorder¹
Older mood stabilising drug (lithium)	50%	292	336	296	381	319	389
Newer mood stabilising drug (valproate)	50%	211	300	273	331	278	351
Older mood stabilising drug +	50%	312	365	322	413	346	422
psychosocial treatment	50%	312	365	322	413	346	422
Newer mood stabilising drug +	50%	232	330	300	365	306	386
psychosocial treatment	50%	232	330	300	365	306	386

Depression
Episodic treatment: older	50%	599	995	920	874	987	891
antidepressant drug (TCA)	50%	599	995	920	874	987	891
Episodic treatment: newer	50%	632	1,049	971	925	1,042	941
antidepressant drug (SSRI)	50%	632	1,049	971	925	1,042	941
Episodic psychosocial treatment	50%	624	1,036	958	936	1,028	927
Episodic psychosocial treatment +	50%	745	1,237	1,144	1,100	1,228	1,107
older antidepressant	50%	745	1,237	1,144	1,100	1,228	1,107
Episodic psychosocial treatment +	50%	745	1,237	1,144	1,100	1,228	1,107
newer antidepressant	50%	745	1,237	1,144	1,100	1,228	1,107
Maintenance psychosocial treatment +	50%	1,174	1,953	1,806	1,789	1,937	1,747
older antidepressant	50%	1,174	1,953	1,806	1,789	1,937	1,747
Maintenance psychosocial treatment +	50%	1,174	1,953	1,806	1,789	1,937	1,747
newer antidepressant	50%	1,174	1,953	1,806	1,789	1,937	1,747

Panic disorder
Anxiolytic drug (benzodiazepine)	50%	144	182	170	183	168	195
Older antidepressant	50%	232	290	272	290	269	312
drug (TCA)	50%	232	290	272	290	269	312
Newer antidepressant drug	50%	245	307	287	307	284	330
(SSRI; generic)	50%	245	307	287	307	284	330
Psychosocial treatment (CBT)	50%	233	292	273	292	270	313
Older antidepressant +	50%	262	329	308	329	304	353
psychosocial treatment	50%	262	329	308	329	304	353
Newer antidepressant +	50%	276	346	324	346	320	372
psychosocial treatment	50%	276	346	324	346	320	372

Results for community-based service model presented here only (hospital-based service model not shown); CBT - cognitive behavioural therapy; DALYs - disability- adjusted life years; SSRI - selective serotonin reuptake inhibitor; TCA - tricyclic antidepressant