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. Author manuscript; available in PMC: 2006 Oct 14.
Published in final edited form as: Circ Res. 2005 Sep 15;97(8):805–812. doi: 10.1161/01.RES.0000186180.47148.7b

Figure 4.

Figure 4

Heme and hemin inhibit BKCa channels in inside-out membrane patches from cerebral artery smooth muscle cells. Bath (ie, intracellular) free [Ca2+] was 10 μmol/L. A, Original recordings at a membrane potential of +40 mV illustrating concentration-dependent BKCa channel inhibition by hemin. B, Concentration-dependent BKCa channel inhibition by hemin at +40 mV. Solid line illustrates Boltzmann fit to the data; n=1, 3, 6, 4, 5, 3, and 11 for 100 pmol/L, 300 pmol/L, 1 nmol/L, 3 nmol/L, 10 nmol/L, 30 nmol/L, and 100 nmol/L, respectively. C, Hemin inhibits BKCa channels at −40 mV. *P<0.05 compared with control.