Table 3.
Frequencies of chromosome abnormalities in untreated or radiation-treated wild-type and mParp1-deficient primary MEFs
| Cell type | End-to-end fusions/chromosomesa | SFEs/chromosomesa | Chromosome breakages/chromosomesa |
|---|---|---|---|
| Untreated | |||
| Wild type | 0/2034 (0) | 6/2034 (0.003) | 1/2034 (0) |
| mParp-/- | 2/2087 (0) | 8/2087 (0.004) | 17/2087 (0.008) |
| X-ray (5 Gy) | |||
| Wild type | 7/2050 (0.003) | 192/2050 (0.094) | 86/2050 (0.042) |
| mParp-/- | 44/2071 (0.021)d | 352/2071 (0.017)b | 269/2071 (0.13)b |
a
Average number of abnormal chromosome events/per chromosome.
b
p value between mParp-/- and wild type yielded a statistical difference of p < 0.01, using a chi-square test. The data were obtained from telomeric-FISH.