Table 1.
Amino acid sequence/positionsa | Sp2 region | NLS type |
---|---|---|
489PGEKRRR495 | C domain | Monopartite |
515KKKH518 | C domain | Monopartite |
515KKK-HVCHIPDCG-KTFRK531 | C/DNA-binding domains | Bipartite |
A computer-assisted screen (http://psort.nibb.ac.jp/) of the human Sp2 amino acid sequence resulted in the identification of the putative nuclear localization sequences listed above. NLS classifications are based on consensus sequences derived previously (Hicks and Raikhel, 1995; Cokol et al., 2000).