Figure 2.

Loss of LIMK1 in skin disorders with a failure of subcorneal cell compaction. (A) Histological appearance of normal and psoriatic (H&E, pso) epidermis stained with hematoxylin and eosin (left-hand panels) and immunostaining of psoriatic epidermis with the antibodies shown. Brackets denote region of cell compaction in normal epidermis and equivalent region in psoriatic epidermis. (B) Other skin diseases with granular layer abnormalities, stained with hematoxylin and eosin (top panels) or immunostained for LIMK1 (bottom panels). (A and B) Immunostained sections were counterstained with DAPI in order to visualize cell nuclei. Scale bars, (A) 50 μm, (B) 100 μm.