Multiple alignments of CHASE5 (A) and CHASE6 (B) domains. Secondary-structure elements and domain abbreviations are described in the legend to Fig. 1 except for HDc, the phosphohydrolase (phosphodiesterase) domain. Species abbreviations: Atum, Agrobacterium tumefaciens; Hal, Halobacterium sp.; Nos, Nostoc (Anabaena) sp.; Paer, Pseudomonas aeruginosa; Syn, Synechocystis sp.; Vcho, Vibrio cholerae.